Jan Lycke Selected Research

9-carboxymethoxymethylguanine

12/2019	An unexpectedly high occurrence of aciclovir-induced neuropsychiatric symptoms in patients treated for herpesvirus CNS infection: a prospective observational study.
5/2006	The aciclovir metabolite CMMG is detectable in the CSF of subjects with neuropsychiatric symptoms during aciclovir and valaciclovir treatment.

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Jan Lycke Research Topics

Disease

48	Multiple Sclerosis 04/2024 - 08/2003
23	Relapsing-Remitting Multiple Sclerosis 09/2023 - 08/2011
5	Infections 12/2023 - 06/2011
5	Inflammation (Inflammations) 01/2020 - 11/2015
3	Disease Progression 02/2024 - 11/2013
3	Demyelinating Diseases (Demyelinating Disease) 06/2023 - 01/2017
2	Chronic Progressive Multiple Sclerosis 01/2024 - 11/2023
2	COVID-19 12/2023 - 01/2022
2	Gliosis 01/2023 - 01/2014
2	Progressive Multifocal Leukoencephalopathy 05/2021 - 06/2016
2	Autoimmune Diseases (Autoimmune Disease) 01/2021 - 10/2014
1	HIV Infections (HIV Infection) 04/2024
1	Pain (Aches) 08/2023
1	Fatigue 02/2023
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2023
1	Encephalomyelitis (Myeloencephalitis) 01/2022
1	Myelitis 01/2022
1	Optic Neuritis (Retrobulbar Neuritis) 01/2022
1	Thyroid Diseases (Thyroid Disease) 01/2021
1	Neoplasms (Cancer) 01/2020
1	Hematologic Neoplasms (Hematological Malignancy) 01/2020
1	Herpesviridae Infections (Herpesvirus Infection) 12/2019
1	Central Nervous System Infections (Central Nervous System Infection) 12/2019
1	Dementia (Dementias) 01/2019
1	Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 10/2016
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 10/2014
1	Myoglobinuria 08/2011
1	Myalgia 08/2011
1	Rhabdomyolysis 08/2011
1	Chickenpox 06/2011
1	Measles 06/2011
1	Rubella (German Measles) 06/2011
1	Herpes Zoster 06/2011
1	Postpoliomyelitis Syndrome (Post-Polio Syndrome) 12/2010
1	Herpes Simplex Encephalitis (Herpes Encephalitis) 05/2006

Drug/Important Bio-Agent (IBA)

16	Biomarkers (Surrogate Marker)IBA 02/2024 - 06/2011
12	Natalizumab (Tysabri)FDA Link 01/2023 - 01/2011
9	Rituximab (Mabthera)FDA Link 02/2024 - 02/2016
9	Alemtuzumab (Campath)FDA Link 01/2023 - 10/2014
5	Fingolimod Hydrochloride (FTY720)FDA Link 12/2023 - 06/2016
3	AntibodiesIBA 01/2023 - 06/2011
3	InterferonsIBA 01/2022 - 08/2011
3	Valacyclovir (Valtrex)FDA LinkGeneric 12/2019 - 08/2003
3	Acyclovir (Aciclovir)FDA LinkGeneric 12/2019 - 08/2003
3	Tumor Necrosis Factor Ligand Superfamily Member 14IBA 01/2019 - 01/2014
2	Immunoglobulin G (IgG)IBA 04/2024 - 11/2013
2	Macrophage Migration-Inhibitory FactorsIBA 01/2024 - 01/2022
2	Messenger RNA (mRNA)IBA 12/2023 - 07/2013
2	teriflunomideIBA 08/2023 - 01/2023
2	Glial Fibrillary Acidic ProteinIBA 01/2023 - 01/2014
2	Dimethyl FumarateIBA 01/2022 - 10/2020
2	Glatiramer Acetate (Copaxone)FDA Link 01/2022 - 01/2020
2	Interferon beta-1a FDA Link 12/2021 - 08/2011
2	Oligoclonal BandsIBA 11/2021 - 11/2013
2	Proteins (Proteins, Gene)FDA Link 09/2021 - 10/2016
2	Interferon-betaIBA 01/2020 - 08/2011
2	Mitoxantrone (Novantrone)FDA LinkGeneric 01/2020 - 10/2016
2	9-carboxymethoxymethylguanineIBA 12/2019 - 05/2006
1	Immunoglobulins (Immunoglobulin)IBA 04/2024
1	VaccinesIBA 12/2023
1	Sulfoglycosphingolipids (Sulfatides)IBA 06/2023
1	Protein Isoforms (Isoforms)IBA 06/2023
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2023
1	NADPH Oxidases (NAD(P)H oxidase)IBA 01/2023
1	Myelin-Oligodendrocyte GlycoproteinIBA 01/2022
1	Immunoglobulin M (IgM)IBA 01/2022
1	High-Temperature Requirement A Serine Peptidase 1IBA 09/2021
1	nitazoxanide (NTZ)FDA Link 05/2021
1	T-Cell Antigen Receptors (T-Cell Receptor)IBA 01/2020
1	Blood Proteins (Serum Proteins)IBA 01/2020
1	AntigensIBA 01/2020
1	ocrelizumabIBA 01/2020
1	GAP-43 Protein (GAP 43 Protein)IBA 11/2019
1	NeopterinIBA 01/2019
1	Retinaldehyde (Retinal)IBA 01/2018
1	OxysterolsIBA 11/2015
1	Monoclonal AntibodiesIBA 11/2015
1	MicroRNAs (MicroRNA)IBA 07/2013
1	Amyloid (Amyloid Fibrils)IBA 04/2013
1	Simvastatin (Zocor)FDA LinkGeneric 08/2011
1	Creatine Kinase (Creatine Phosphokinase)IBA 08/2011
1	Measles VaccineIBA 06/2011
1	Peroxidase (Myeloperoxidase)IBA 12/2010

Therapy/Procedure

22	Therapeutics 12/2023 - 09/2007
3	Stem Cell Transplantation 09/2023 - 10/2014
3	Hematopoietic Stem Cell Transplantation 01/2021 - 01/2020
1	Immunotherapy 08/2023
1	Critical Care (Surgical Intensive Care) 01/2022
1	Aftercare (After-Treatment) 01/2021
1	Injections 01/2020
1	Off-Label Use 01/2020